Search results for "Diabetes mellitus tipo 2"

showing 10 items of 15 documents

Efecto de la Sobrecarga oral con grasa insaturada en los marcadores de estrés oxidativo y expresión de ARN lifomonocitos en sujeto con Diabetes Melli…

2016

La enfermedad cardiovascular (ECV) es la principal causa de mortalidad en nuestro medio. Está causada por diferentes factores de riesgo entre los que se encuentran la diabetes mellitus (DM), el tabaquismo, la hipertensión arterial (HTA) y la dislipemia (DL). El termino DM describe diferentes enfermedades del metabolismo de los carbohidratos, que se caracterizan por la hiperglucemia crónica y son causadas por el déficit de secreción de insulina o por la resistencia a la acción de la misma. La causa mas frecuente de mortalidad en los pacientes con DM2 es la ECV. El riesgo cardiovascular en la DM2 viene mediado no solo por la hiperglucemia, sino también por el resto de factores de riesgo clási…

diabetes mellitus tipo 2estrés oxidativoARN linfomonocitos:CIENCIAS MÉDICAS ::Medicina interna::Endocrinología [UNESCO]grasa insaturadaUNESCO::CIENCIAS MÉDICAS ::Medicina interna::Endocrinologíasobrecarga oral con grasa
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Patients' and physicians' preferences for type 2 diabetes mellitus treatments in Spain and Portugal: a discrete choice experiment.

2015

Objective: To assess Spanish and Portuguese patients' and physicians' preferences regarding type 2 diabetes mellitus (T2DM) treatments and the monthly willingness to pay (WTP) to gain benefits or avoid side effects. Methods: An observational, multicenter, exploratory study focused on routine clinical practice in Spain and Portugal. Physicians were recruited from multiple hospitals and outpatient clinics, while patients were recruited from eleven centers operating in the public health care system in different autonomous communities in Spain and Portugal. Preferences were measured via a discrete choice experiment by rating multiple T2DM medication attributes. Data were analyzed using the cond…

:Geographicals::Geographic Locations::Europe::Portugal [Medical Subject Headings]cardiovascular riskHbA1cendocrine system diseases:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings]:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hypoglycemia [Medical Subject Headings]:Disciplines and Occupations::Health Occupations::Medicine::Public Health [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]:Named Groups::Persons::Occupational Groups::Health Personnel::Physicians [Medical Subject Headings]HbA(1c)HbA:Diseases::Pathological Conditions Signs and Symptoms::Signs and Symptoms::Body Weight::Body Weight Changes::Weight Loss [Medical Subject Headings]:Diseases::Cardiovascular Diseases [Medical Subject Headings]preferences:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]diabetesnutritional and metabolic diseasesPeso corporalweightPérdida de peso:Health Care::Health Care Facilities Manpower and Services::Health Facilities::Ambulatory Care Facilities [Medical Subject Headings]Diabetes mellitus tipo 2:Diseases::Pathological Conditions Signs and Symptoms::Signs and Symptoms::Signs and Symptoms Digestive::Nausea [Medical Subject Headings]hypoglycemia:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Logistic Models [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Signs and Symptoms::Body Weight [Medical Subject Headings]:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus Type 2 [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents [Medical Subject Headings]Enfermedades cardiovascularesHipoglucemiawillingness to pay:Check Tags [Medical Subject Headings]discrete choice model
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Grip Strength, Neurocognition, and Social Functioning in People WithType-2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizo…

2020

[Background] Frailty is a common syndrome among older adults and patients with several comorbidities. Grip strength (GS) is a representative parameter of frailty because it is a valid indicator of current and long-term physical conditions in the general population and patients with severe mental illnesses (SMIs). Physical and cognitive capacities of people with SMIs are usually impaired; however, their relationship with frailty or social functioning have not been studied to date. The current study aimed to determine if GS is a valid predictor of changes in cognitive performance and social functioning in patients with type-2 diabetes mellitus and SMIs.

:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Affective Disorders Psychotic::Bipolar Disorder [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicine:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder Major [Medical Subject Headings]Social functioningPsychology030212 general & internal medicineType-2 diabetes mellitusCognitive performancecognitive performanceGeneral PsychologyOriginal Research:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]:Persons::Persons::Patients::Outpatients [Medical Subject Headings]education.field_of_studyFrailtyCognition:Disciplines and Occupations::Natural Science Disciplines::Physics::Electronics [Medical Subject Headings]Type-2 diabetesmellitusFragilidadDiabetes mellitus tipo 2SchizophreniaTrastornos mentalesMajor depressive disorder:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus Type 2 [Medical Subject Headings]PsychologyClinical psychologyFuerza de la manoPopulationlcsh:BF1-990frailty03 medical and health sciencessevere mental illness:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]Severe mental illnessmedicine:Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia [Medical Subject Headings]Effects of sleep deprivation on cognitive performanceBipolar disordereducation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings]:Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Muscle Strength::Hand Strength [Medical Subject Headings]Type 2 Diabetes Mellitustype-2 diabetes mellitusmedicine.diseasesocial functioninglcsh:PsychologyGrip strengthgrip strengthInteracción socialNeurocognitive:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance [Medical Subject Headings]030217 neurology & neurosurgeryFrontiers in Psychology
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Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.

2012

Journal Article; Research Support, Non-U.S. Gov't; SUMMARY The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated. METHODS 1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in b…

MaleAnatomy and PhysiologyEspañaDiabetes Mellitus Tipo 2:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Type 2 diabetesResistencia a la InsulinaVariación Genética:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]EndocrinologyPolymorphism (computer science)Risk FactorsAnálisis de RegresiónFactores de Riesgo:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]Geneticseducation.field_of_studyMultidisciplinaryAdultoQRMiddle AgedCardiovascular Diseases:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus Type 2 [Medical Subject Headings]Regression AnalysisMedicineFemale:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Variation [Medical Subject Headings]Fatty Acid Binding Protein 3Research ArticleAdult:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings]GenotypeSciencePopulation:Check Tags::Male [Medical Subject Headings]Single-nucleotide polymorphismEndocrine SystemBiologyFatty Acid-Binding ProteinsPolymorphism Single Nucleotide:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings]Insulin resistanceGenetic variation:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineGeneticsHumans:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]education:Diseases::Cardiovascular Diseases [Medical Subject Headings]Biology:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings]AllelesAgedDiabetic Endocrinology:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide [Medical Subject Headings]Polymorphism GeneticEndocrine PhysiologyHaplotypeGenetic Variation:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic [Medical Subject Headings]medicine.diseaseObesity:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Carrier Proteins::Fatty Acid-Binding Proteins [Medical Subject Headings]:Check Tags::Female [Medical Subject Headings]Diabetes Mellitus Type 2HaplotypesSpainMetabolic DisordersMutationInsulin ResistancePopulation GeneticsPloS one
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Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome

2021

Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p &lt

Acute coronary syndromemedicine.medical_specialtyAnemiaMujermedicine.medical_treatment:enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus [ENFERMEDADES]Enfermedad cardiovascularAnciano:Otros calificadores::/diagnóstico [Otros calificadores]DonesDietética y nutriciónDiseaseMalalties coronàriesRevascularizationelderlyArticleCoronary diseasesInfarto del miocardio sin elevación del STnon-ST-segment elevation acute coronary syndromesDiabetes mellitusInternal medicine:Other subheadings::/diagnosis [Other subheadings]medicineClinical endpointEndocrinologíaWomen:Diagnosis::Prognosis [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Diabetis - Prognosi:diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Diabetisbusiness.industryST elevationDiabetesRGeneral Medicinemedicine.disease:Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [DISEASES]Diabetes mellitus tipo 2diabetes mellitusDiferències entre sexes:enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::síndrome coronario agudo [ENFERMEDADES]Medicinewomenbusiness:Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Acute Coronary Syndrome [DISEASES]Kidney disease
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Identificación de variantes genéticas poco frecuentes y raras en Diabetes mellitus tipo 2 mediante secuenciación de exoma

2015

Identificación de variantes genéticas poco frecuentes y raras en diabetes mellitus tipo 2 mediante secuenciación de exoma. La diabetes mellitus tipo 2 (DM2) se ha convertido en una epidemia global que contribuye significativamente a la morbi-mortalidad prematura. La DM2 es resultado de múltiples factores, incluyendo ambientales, genéticos y adquiridos. Se ha demostrado que la heredabilidad de la DM2 se encuentra alrededor del 70%. No obstante, los estudios realizados sólo han podido identificar una pequeña proporción del componente genético de la enfermedad. El resto del componente podría residir, en parte, en variantes genéticas poco frecuentes (MAF 20 y con valores predictivos de alteraci…

UNESCO::CIENCIAS DE LA VIDA::GenéticaDiabetes mellitus tipo 2:CIENCIAS DE LA VIDA::Genética [UNESCO]ExomaVariantes genéticas poco frecuentes y raras
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Retroespalhamento luminoso das córneas de pacientes com diabete melito dependente e não dependente de insulina: estudo piloto

2017

ABSTRACT Purpose: To compare central corneal backscatter obtained from Scheimpflug images between patients with insulin-dependent and non-insulin-dependent diabetes mellitus (IDDM and NIDDM, respectively) and healthy controls. Methods: Seven patients with IDDM (7 eyes), eleven patients with NIDDM (11 eyes), and sixteen healthy subjects (16 eyes) were included in this pilot study. Scheimpflug imaging system (Pentacam, Oculus Inc., Germany) was used to obtain optical sections of the cornea. Seven meridians were analyzed for each eye, oriented from 70° to 110°. Optical density values for the central 3-mm and 5-mm zones of the cornea were obtained by image analysis using external software. Resu…

MaleVisual acuityCorneal Pachymetrygenetic structuresScheimpflug principleVisual AcuityPilot ProjectsDiagnostic Techniques OphthalmologicalCorneal DiseasesCornea0302 clinical medicineDiabetes mellituslcsh:OphthalmologyReference ValuesCorneaMedicineCorneal pachymetrymedicine.diagnostic_testCorneal DiseasesAge FactorsScheimpflug imagingGeneral MedicineMiddle AgedCorneal topographymedicine.anatomical_structureDiabetes mellitus tipo 2Diabetes mellitus tipo 1Femalemedicine.symptomAdultmedicine.medical_specialtyProjetos pilotoStatistics Nonparametric03 medical and health sciencesAnterior Eye SegmentDiabetes mellitusOphthalmologyHumansScheimpflug Topografia da córneaAgedbusiness.industryCase-control studyReproducibility of ResultsDiabetes mellitus type 1Diabetes mellitus type 2medicine.diseaseeye diseasesOphthalmologyPilot projectDiabetes Mellitus Type 1Diabetes Mellitus Type 2lcsh:RE1-994Case-Control Studies030221 ophthalmology & optometrysense organsCorneal topographybusiness030217 neurology & neurosurgery
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Metilación del ADN de adipocitos en sujetos con obesidad mórbida

2019

Introducción: La obesidad y la diabetes mellitus tipo 2 (DM2) son dos patologías con elevada prevalencia e importante morbimortalidad asociada en nuestro medio. La obesidad, mediante diferentes mecanismos en los que juega un importante papel el tejido adiposo, se asocia con resistencia a la insulina, la cual suele preceder a la aparición de diabetes mellitus tipo 2. Existen alteraciones genéticas que predisponen al desarrollo de resistencia a la insulina y DM2 en pacientes con obesidad, pero no explican la totalidad del riesgo. Se postula que la epigenética, que se define como modificaciones heredables sobre los genes que varían su función sin necesidad de alteración de la secuencia de ADN,…

Diabetes mellitus tipo 2AdipocitosObesidad mórbida:CIENCIAS MÉDICAS ::Medicina interna::Endocrinología [UNESCO]EpigenéticaUNESCO::CIENCIAS MÉDICAS ::Medicina interna::Endocrinología
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Documento de consenso de la Sociedad Española de Arteriosclerosis (SEA) para la prevención y tratamiento de la enfermedad cardiovascular en la diabet…

2018

Este artículo se encuentra disponible en la siguiente URL: https://www.elsevier.es/es-revista-clinica-e-investigacion-arteriosclerosis-15-articulo-documento-consenso-sociedad-espanola-arteriosclerosis-S0214916818300846 This is the pre-peer reviewed version of the following article: Ruiz-García, A., Arranz-Martínez, E., Morón-Merchante, I., Pascual-Fuster, V., Tamarit, JJ., Trias-Villagut, F. et al. (2018). Documento de consenso de la Sociedad Española de Arteriosclerosis (SEA) para la prevención y tratamiento de la enfermedad cardiovascular en la diabetes mellitus tipo 2. Clínica e Investigación en Arteriosclerosis, vol. 30, supl. 1 (julio), pp. 1-19, which has been published in final form …

Blood pressure controlmedicine.medical_specialtyHipertensión.FarmacologíaEnfermedad cardiovascularDisease030204 cardiovascular system & hematologyDiabetes - Farmacoterapia.Enfermedades cardiovasculares - Factores de riesgo - Tratamiento.Diabetes - Chemotherapy.03 medical and health sciencesTratamiento médicoCardiovascular system - Diseases - Risk factors - Treatment.0302 clinical medicineDiabetes mellitusHypertension.MedicinePharmacology (medical)Lipid controlHypoglycemic drugs030212 general & internal medicineIntensive care medicineInhibidores de agregación plaquetariabusiness.industryHypertriglyceridemiaType 2 Diabetes Mellitusnutritional and metabolic diseasesArteriosclerosismedicine.diseaseDiabetes mellitus tipo 2Cardiology and Cardiovascular Medicinebusiness
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Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

2019

Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active ag…

Enfermedad cardiovascularPharmaceutical SciencePharmacology01 natural sciencesAnalytical Chemistry//purl.org/becyt/ford/1 [https]Tratamiento médicoDPP-4Drug DiscoveryReceptorchemistry.chemical_classificationGIPGLUCAGON-LIKE PEPTIDE-1digestive oral and skin physiologyGlucagon-like peptide-1Diabetes mellitus tipo 2HomeopatíaINCRETINSMolecular MedicineCIENCIAS NATURALES Y EXACTAShormones hormone substitutes and hormone antagonistsendocrine systemOtras Ciencias BiológicasIncretinIncretinsCiencias BiológicasDiabetes mellitusDiabetes MellitusmedicineAnimalsHumansHypoglycemic Agents//purl.org/becyt/ford/1.6 [https]Dipeptidyl peptidase-4PharmacologyBiological ProductsPlants MedicinalGuar gum010405 organic chemistryOrganic ChemistryGLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDEmedicine.diseaseDIPEPTIDYL PEPTIDASE-40104 chemical sciences010404 medicinal & biomolecular chemistryEnzymeComplementary and alternative medicinechemistryGLP-1PhytotherapyHormone
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